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. 2018 Apr 3;8:5506. doi: 10.1038/s41598-018-23901-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Several novel genes are differentially expressed in the Bhlhe23^−/− retina at postnatal day 7. Representative box plots showing the results of RT-PCR experiments to confirm the differential expression of novel genes (identified by RNAseq) in the Bhlhe23^−/− retina vs wildtype (WT) at PN7 (n = 6 litter-matched pairs). Four genes that were significantly down-regulated were Car8 (p-value = 0.018), Il1rap (p-value = 0.024), Gm11619 (p-value = 8.6e⁻⁴) and A230077H06Rik (p-value = 8.2e⁻³). The mean expression of Slco4a1 was lower in the Bhlhe23^−/− retina vs WT but did not reach statistical significance (p-value = 0.069).