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. 2018 Apr 3;8:5506. doi: 10.1038/s41598-018-23901-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Regulators of rod bipolar cell development are involved in the cell cycle, synaptic signalling and transcriptional/translational activity. Gene ontologies and biological pathways involved in synaptic signalling, regulation of the cell cycle and transcriptional/translational activity are enriched in the Bhlhe23^−/− retina at PN7 with p_adj ≤ 0.25. (a) Figure showing enriched gene ontologies clustered into 8 groups that share >50% of genes. Node size represents the statistical significance of enrichment. Node shape corresponds to ontology source: circle = Gene ontology (GO) BiologicalProcess; diamond = GO CellularComponent; hexagon = Kyoto Encylopedia of Genes and Genomes (KEGG) pathway; octagon = REACTOME. (b) Table showing enriched gene ontologies and biological pathways in the Bhlhe23^−/− retina at PN7, the corresponding gene names and the percentage (%) of the total number of genes in the PN7 transcriptome associated with the Gene Ontology (GO) term. Colours correspond to functional groups in (a).