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. 2018 Apr 3;8:5439. doi: 10.1038/s41598-018-23802-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic representation of the putative OTA biosynthetic gene cluster 38, located on scaffold 12 (931076-971429 nt). Arrows represent genes and point in the direction of transcription. The role of the polyketide synthase gene (AcOTApks), the non-ribosomal peptide synthetase gene (AcOTAnrps) and the halogenase gene (AcOTAhal) in the biosynthetic pathway of OTA has been determined by gene inactivation^10,12,20. The cytochrome P450 monooxygenase gene (AcOTAp450) and the bzip transcription factor gene (AcOTAbZip) are putatively involved in OTA biosynthesis^20,21.