Table 1.
Demographic features of PiB(−) and PiB(+) aMCI with clinical follow-up.
| PiB(−) aMCI | PiB(+) aMCI | p value | |
|---|---|---|---|
| N | 16 | 31 | |
| Baseline age: years | 71.6 ± 6.3 | 70.2 ± 8.7 | 0.570 |
| Gender, female | 9 (56.3) | 11 (35.5) | 0.172 |
| Education, years | 11.5 ± 6.1 | 13.6 ± 3.3 | 0.218 |
| Geriatric Depression Scale | 15.1 ± 7.7 | 9.6 ± 6.0 | 0.010 |
| APOE4 carrier | 0/16 (0) | 19/29 (65.5) | <0.001 |
| Baseline PiB uptake | 1.32 ± 0.13 | 2.16 ± 0.35 | <0.001 |
| Annual changes of global PiB retention ratio* | 0.01 ± 0.04 | 0.03 ± 0.06 | 0.258 |
| Follow-up duration, years | 3.8 ± 1.5 | 3.5 ± 1.3 | 0.307 |
| Progression to dementia | 4 (25.0) | 22 (71.0) | NA |
AD = Alzheimer’s disease; APOE4 = apolipoprotein E4; aMCI = amnestic mild cognitive impairment; PiB(−) aMCI = Pittsburgh compound B negative amnestic mild cognitive impairment; PiB(+) aMCI = Pittsburgh compound B positive amnestic mild cognitive impairment; NA = not applicable. Data are expressed in mean ± standard deviation or number (percentage). P values are results of independent t tests or chi-square tests as appropriate. *Nine of 16 PiB(−) aMCI patients and 21 of 31 PiB(+) aMCI patients performed follow-up PiB-PET scans.