Table 2.
Longitudinal changes of neuropsychological test scores in PiB(−) and PiB(+) aMCI.
| Neuropsychological test | PiB(−) aMCI* | PiB(+) aMCI* | PiB(−) vs. PiB(+) aMCI** | |||
|---|---|---|---|---|---|---|
| β (SE) | p | β (SE) | p | β (SE) | p | |
| Digit span forward | 0.14 (0.11) | 0.922 | 0.05 (0.07) | 0.570 | 0.07 (0.12) | 0.910 |
| Digit span backward | 0.08 (0.08) | 0.755 | −0.06 (0.08) | 0.507 | 0.16 (0.12) | 0.418 |
| Calculation | 0.05 (0.15) | 0.868 | −0.23 (0.08) | 0.007 | 0.33 (0.14) | 0.075 |
| K-BNT | 0.29 (0.66) | 0.806 | −1.04 (0.71) | 0.205 | 1.39 (1.10) | 0.400 |
| RCFT copy | 0.04 (0.35) | 0.912 | −0.25 (0.30) | 0.500 | 0.27 (0.48) | 0.803 |
| SVLT immediate recall | 0.30 (0.28) | 0.839 | −0.66 (0.20) | 0.009 | 0.85 (0.35) | 0.089 |
| SVLT delayed recall | −0.24 (0.20) | 0.843 | −0.34 (0.14) | 0.038 | 0.04 (0.24) | 0.932 |
| SVLT recognition | −0.38 (0.21) | >0.999 | −0.29 (0.20) | 0.196 | −0.12 (0.30) | 0.848 |
| RCFT immediate recall | −0.44 (0.29) | >0.999 | −0.61 (0.30) | 0.085 | 0.25 (0.44) | 0.749 |
| RCFT delayed recall | −0.33 (0.36) | 0.697 | −0.95 (0.30) | 0.006 | 0.62 (0.46) | 0.376 |
| RCFT recognition | −0.09 (0.19) | 0.828 | −0.30 (0.16) | 0.111 | 0.06 (0.26) | 0.837 |
| COWAT animal | −0.09 (0.32) | 0.825 | −0.95 (0.25) | 0.002 | 0.96 (0.39) | 0.069 |
| COWAT supermarket | 0.23 (0.42) | 0.826 | −0.70 (0.28) | 0.110 | 1.12 (0.64) | 0.244 |
| COWAT phonemic | −0.57 (0.85) | 0.780 | 0.21 (0.83) | 0.798 | 0.02 (1.36) | 0.991 |
| Stroop color reading | −2.51 (1.86) | >0.999 | −3.78 (1.20) | 0.008 | 1.21 (2.04) | 0.855 |
| MMSE | −0.18 (0.07) | 0.708 | −1.18 (0.18) | <0.001 | 0.91 (0.28) | 0.017 |
| CDR Sum of Boxes | 0.10 (0.12) | 0.702 | 0.65 (0.09) | <0.001 | −0.48 (0.15) | 0.017 |
PiB(−) aMCI = Pittsburgh compound B negative amnestic mild cognitive impairment; PiB(+) aMCI = Pittsburgh compound B positive amnestic mild cognitive impairment; SE = standard error; K-BNT = Korean version of Boston Naming Test; RCFT = Rey-Osterrieth Figure Test; SVLT = Seoul Verbal Learning Test; COWAT = Controlled Oral Word Association Test; MMSE = Mini-mental Status Examination; CDR = Clinical Dementia Rating. Data are results of linear mixed effect models for neuropsychological scores using age, sex, education, and time interval from baseline evaluation as covariates. *Results of linear mixed models separately performed in PiB(+) or PiB(−) aMCI group using time interval from baseline evaluation as a predictor. **Results of linear mixed models in total aMCI patients using the interaction between group and time interval as a predictor. P values are corrected for multiple comparisons using false discovery rate correction.