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. 2018 Mar 28;10:3. doi: 10.3389/fnsyn.2018.00003

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Copyright © 2018 Hartner and Schrader.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Norepinephrine significantly increased miniature IPSC frequency and decay time, but not amplitude, in MEC – LII principal cells. (A) Twenty seconds (Top) and 2 s (Bottom) of mIPSC voltage-clamp recordings in the presence of TTX representative of control (left) and NE (right) conditions. (B) NE significantly increased average mIPSC frequency. (C) NE did not significantly alter m IPSC amplitude. (D) NE significantly increased average mIPSC decay time. (E) NE significantly increased mIPSC frequency and decay time, but not amplitude, when normalized and compared to the corresponding control group average (n = 19). (^∗∗∗p < 0.001, ^∗∗∗∗p < 0.0001).