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. 2018 Mar 28;10:3. doi: 10.3389/fnsyn.2018.00003

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Copyright © 2018 Hartner and Schrader.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pre-treatment with prazosin, a specific α1AR antagonist blocks NE-induced sIPSC frequency and amplitude increases. (A) Twenty seconds (top) and 2 s (bottom) of sIPSC voltage-clamp recordings in prazosin (left) and prazosin + NE (right) conditions. Prazosin alone had no significant effect on sIPSC frequency (B) or amplitude (C), and prazosin blocked the effects of NE on frequency (B) and amplitude (C) (n = 6).