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. 2018 Mar 28;10:3. doi: 10.3389/fnsyn.2018.00003

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Copyright © 2018 Hartner and Schrader.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Phenylephrine, an agonist of α1 adrenoreceptors increased spontaneous IPSC frequency in a subset of neurons, and had no effect on amplitude or decay time. (A) Twenty seconds (Top) and 2 s (Bottom) of sIPSC voltage-clamp recordings representative of control (left) and PHE (right) conditions. (B) PHE failed to significantly increase average sIPSC frequency (n = 10). (C) PHE had no significant effect on average sIPSC amplitude. (D) PHE significantly increased average sIPSC frequency in the 5 PHE-sensitive cells, but had no significant effect in the other five cells. (E) summary plots of the average effect of agonists of the adrenoreceptors on spontaneous IPSCs. NE significantly increased sIPSC frequency and amplitude and this was partially mimicked by phenylephrine, the α1AR agonist.