Table 1.

Overview of the screening and the study visits. On the study days, the pharmacological challenge is administered at time point 0.

Assessments		Screening visit	Study visits (1, 2, 3) with time points (hours)
			-1.5	0	1.0	1.5	2.0	2.5	3.0	3.5
Clinical measures
	Clinical proceduresa	Xb
	Vital signs	X	X			X				X
	12-lead electrocardiogram	X	X
	Urinalysis	X	X
	Clinical laboratoryc	X
	Pharmacokinetics blood sampling		X		X			X		X
	Drug administration			X
Central nervous system tests
	Eye movements	X	X		X			X		X
	Adaptive tracker	X	X		X			X		X
	Visual Analog Scales	X	X		X			X		X
	Pharmaco-electroencephalography		X		X			X		X
	Visual Verbal Learning Test-15	X					X	X	X
	Facial recognition task	X						X
	N-back task	X	X		X			X		X
	Stop Signal test	X	X		X			X		X
Magnetic resonance imaging		X

^aClinical procedures include medical history and medication use, Mini-Mental State Examination, Clinical Dementia Rating scale, and physical examination.

^bX: the assessment was performed.

^cClinical laboratory includes hematology and blood biochemistry.