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. 2018 Mar 1;8(3):405–421.

Figure 4.

Figure 4

HMGA2 is a direct target of miR-337 in HCC. A. MiR-337 and its putative binding sequences in the 3’-UTR of HMGA2. Mutation was generated on the 3’-UTR of HMGA2 in the complementary sites for the seed region of miR-337. B. HepG2 and Hep3B cells were cotransfected with miR-337 mimics or miR-NC and wild-type or mutant HMGA2 3’-UTR. The relative firefly luciferase activity was determined at 48 h posttransfection. *P<0.05 compared with miR-NC. C, D. HepG2 and Hep3B cells that were transfected with miR-337 mimics or miR-NC were subjected to RT-qPCR and Western blot analysis for detection of HMGA2 mRNA and protein expression, respectively. *P<0.05 compared with miR-NC.