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. 2018 Mar 1;8(3):435–449.

Figure 4.

Figure 4

Down-regulation of IGF-1R suppresses the proliferation, colony formation, migration and invasion and increases the apoptosis of SW480 and HCT116 cells. A. Transfection with IGF-1R siRNA efficiently knocked down IGF-1R expression in SW480 and HCT116 cells. *P < 0.05 vs. NC siRNA. B, C. CCK-8 and colony formation assays were conducted to examine the effects of IGF-1R knockdown on the proliferation and colony formation of SW480 and HCT116 cells. *P < 0.05 vs. NC siRNA. D. Flow cytometric analysis was conducted to investigate the effect of IGF-1R knockdown on SW480 and HCT116 cell apoptosis. *P < 0.05 vs. NC siRNA. E, F. Effect of IGF-1R knockdown on the migration and invasion of SW480 and HCT116 cells was assessed using Transwell assay. *P < 0.05 vs. NC siRNA.