Table 2.
Interesting significant GO terms for the SMYD3 knockdown PPI network
| Significant GO list | Term name | P-value corrected with Bonferroni |
|---|---|---|
| Lipid metabolism-related terms | ||
| GO:0006629 | Lipid metabolic process | 1.06E-8 |
| GO:0006631 | Fatty acid metabolic process | 2.99E-11 |
| GO:0008610 | Lipid biosynthetic process | 2.18E-4 |
| GO:0019216 | Regulation of lipid metabolic process | 5.81E-4 |
| GO:0044255 | Cellular lipid metabolic process | 6.20E-9 |
| Signal regulation-related terms | ||
| GO:0007167 | Enzyme-linked receptor protein signaling pathway | 4.75E-6 |
| GO:0070848 | Response to growth factor stimulus | 1.32E-4 |
| GO:0050790 | Regulation of catalytic activity | 4.67E-5 |
| GO:00801340 | Regulation of response to stress | 1.10E-5 |
| GO:00435490 | Regulation of kinase activity | 0.002 |
| GO:00513380 | Regulation of transferase activity | 5.07E-4 |
| GO:00305180 | Intracellular steroid hormone receptor signaling pathway | 4.89E-4 |
| GO:00230560 | Positive regulation of signaling | 0.009 |
| GO:00071690 | Transmembrane receptor protein tyrosine kinase signaling pathway | 1.84E-5 |
| Metabolic or catabolic-associated terms | ||
| GO:00512480 | Negative regulation of protein metabolic process | 4.28E-5 |
| GO:00421760 | Regulation of protein catabolic process | 3.55E-4 |
| GO:00313250 | Positive regulation of cellular metabolic process | 9.07E-10 |
| GO:00197520 | Carboxylic acid metabolic process | 9.23E-11 |
| GO:00442570 | Cellular protein catabolic process | 7.64E-7 |
| Stimulus-related terms | ||
| GO:00485450 | Response to steroid hormone stimulus | 1.05E-5 |
| GO:00328700 | Cellular response to hormone stimulus | 2.20E-8 |
| GO:00100330 | Response to organic substance | 5.24E-17 |
| GO:00094160 | Response to light stimulus | 0.008 |
| GO:00069740 | Response to DNA damage stimulus | 2.05E-4 |
| GO:00714950 | Cellular response to endogenous stimulus | 2.99E-9 |