Table 1.
Immunoregulatory factors | Main source | Mechanisms of immune regulation | Possible effect | Reference |
---|---|---|---|---|
Arg-1 | DCs and other myeloid cells |
|
|
[88] |
TGF-β & IL-10 | Tumor cells, TAM, Treg cells, DCs |
|
|
[91], [93], [94], [95], [96] |
IFN-γ | Activated T cells |
|
|
[88], [89], [95] |
PD-L1 | Tumor cells, APCs |
|
|
[75], [93], [130] |
PD-1 | T cells |
|
|
[93], [132] |
CTLA-4 | T cells |
|
|
[107], [108], [110] |
IDO-1 | Tumor cells, DCs |
|
|
[88], [89], [122], [123], [124] |