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. 2018 Apr 3;18:376. doi: 10.1186/s12885-018-4281-1

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Impact of cyclic treatment on the cell population. In each treatment interval, either high dosage (H) or low dosage (L) treatment is applied.Top: Population composition between dormant (D) and rapidly proliferating (P) cells displayed by the relative fraction of both phenotypes under changing conditions. Middle panel: Average growth rate of the whole population under changing treatment condition. A negative growth rate only occurs in phases of strong treatment. Bottom panel: Absolute number of all tumor cells, P and D phenotype, assuming exponential growth with the given average growth rate (parameters: dormant cell growth rate ε = 0, conversion rate σ = 0.01, high dosage effect λ_H = 1, low dosage effect λ_L = 0.25)