Table 2.
The androstanediol (DIOL) and testosterone production in rat immature Leydig cells after piperine treatment.
| DIOL (ng/106 cells 24 h) |
Testosterone (ng/106 cells 24 h) |
|||
|---|---|---|---|---|
| Control | Piperine | Control | Piperine | |
| Basal | 10.00 ± 3.66 | 26.92 ± 6.56∗∗ | 2.31 ± 1.41 | 3.22 ± 0.61 |
| LH | 16.63 ± 7.67 | 70.23 ± 5.49∗∗∗ | 7.31 ± 4.73 | 30.04 ± 5.51∗∗∗ |
| 8BR | 17.68 ± 3.63 | 62.62 ± 11.74∗∗∗ | 8.54 ± 29.57 | 29.57 ± 4.70∗∗∗ |
| 22R | 25.48 ± 2.41 | 25.74 ± 2.80 | 20.36 ± 7.24 | 32.43 ± 1.92∗ |
| P5 | 41.09 ± 3.55 | 29.22 ± 7.79∗ | 36.68 ± 2.02 | 40.85 ± 3.83 |
| P4 | 33.75 ± 5.22 | 53.37 ± 6.70∗∗ | 32.73 ± 6.42 | 36.08 ± 6.23 |
| D4 | 49.77 ± 3.03 | 50.32 ± 4.25 | 36.30 ± 2.38 | 33.12 ± 3.35 |
| T | 57.22 ± 7.88 | 53.42 ± 2.37 | ||
Mean ± SEM, n = 6. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 indicates significant difference when compare to the control. LH, luteinizing hormone; 8BR, 8bromo-cAMP; 22R, 22R-OH-cholesterol; P5, pregnenolone; P4, progesterone; D4, androstenedione; T, testosterone.