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. 2018 Apr 4;15:9. doi: 10.1186/s12987-018-0094-5

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Diblock copolymer treatment rescues defective barrier function of ccALD-iBMECs. a Chemical structures of polymers utilized for treatment. Poloxamer 188 is a triblock copolymer of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO); E₁₈₂P₁₆t is a diblock copolymer of PEO and PPO with a tert-butoxy end group on the PPO block. b Maximum TEER of WT1- and ccALD3-iBMECs treated with 1 mM of P188 or E₁₈₂P₁₆t. Treatment with 1 mM E₁₈₂P₁₆t resulted in improved ccALD-iBMEC barrier function. Data shown from four independent experiments with three biological replicates each (n = 12)