Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Apr 3;6:25. doi: 10.1186/s40478-018-0527-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 2 — Immunohistochemical study of SphK2 protein expression and Aβ deposits. a Double labeling of SphK2 and Aβ in AD brain sections (n = 25) from frontal (a1) entorhinal cortex (a2) and CA1 hippocampus (a3). Images were taken at 40× magnification (Scale bars represent 20 μm). Black arrows show SphK2 positive neurons, green arrows show SphK2 negative neurons and asterisks show SphK2 positive oligodendrocytes. b Scatter plots depicting the relationship between density of amyloid deposits or Aβ surface percentage (x axis) and SphK2 expression (y axis) in frontal cortex (b1), entorhinal cortex (b2) and CA1 (b3). Regression lines are displayed. c Scatter plots depicting the relationship between number of focal plaques number (x axis) and SphK2 expression (y axis) in frontal cortex (c1), entorhinal cortex (c2) and CA1 (c3). Regression lines are displayed. The results are based on evaluation of 5305 neurons in the frontal cortex, 3238 neurons in entorhinal cortex and 3198 neurons in CA1