Table 3.
Change in variables in obese with relative GHD children treated with GH vs control group for 6 months
| Variable | rhGH group (n = 23) | control group (n = 20) | P value |
|---|---|---|---|
| BMI SDS | 2.32(0.85) | 2.80(0.61) | 0.041* |
| IGF-1(ng/ml) | 702.91(246.03) | 348.3(131.93) | < 0.001* |
| TC(mmol/L) | 4.14(0.73) | 4.29(0.99) | 0.584 |
| HDL-C (mmol/L) | 1.45(0.40) | 1.19(0.23) | 0.016*# |
| LDL-C (mmol/L) | 2.20(0.45) | 2.63(0.76) | 0.027* |
| TG(mmol/L) | 1.02(0.38) | 1.18(0.45) | 0.261# |
| ALT(U/L) | 16.70(6.72) | 45.20(46.62) | 0.002*# |
| AST(U/L) | 21.26(5.72) | 32.3(17.68) | 0.006*# |
| Insulin(uIU/mL) | 27.06(10.99) | 23.26(9.78) | 0.241 |
| FBG(mmol/L) | 5.46(0.41) | 5.25(0.48) | 0.123 |
| HOMA-IR | 6.62(2.86) | 5.44(2.38) | 0.152 |
| HbA1c (%) | 5.61(0.34) | 5.64(0.30) | 0.79 |
BMI SDS body mass index standard deviation scores, IGF-1 Insulin-like growth factor 1, TC total cholesterol, HDL-C High density lipoprotein cholesterol, LDL-C Low density lipoprotein cholesterol, TG triglycerides, ALT alanine aminotransferase, AST aspartate aminotransferase, FBG fasting blood glucose, HOMA-IR homeostasis model assessment of IR, HbA1c Glycosylated haemoglobin
*P<0.05
#P value reported for log transformed values, but values in the table represent a back transformation to the original