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. 2018 Apr 4;12:33. doi: 10.1186/s12918-018-0554-1

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig.
2 — Transcriptomic profiling of BRAF inhibitor resistance in cellular models of malignant melanoma. a Establishing cellular models of mitogen activated protein kinase inhibitor resistance using SK-MEL-28 malignant melanoma cell line and the BRAF inhibitor, vemurafenib. b Transcriptomics RNA-Seq analysis identifies 980 differentially expressed genes between BRAF inhibitor-resistant (BRAFi-R) cellular model vs control. c Enrichment analysis of up- and downregulated gene sets shows shift in metabolic and signaling pathways. d Validation by transcriptomic profiling of identified genes by RT-qPCR. e Comparison and validation of resistance model using melanoma cell lines SK-MEL-28 and A375 by transcriptomics RT-qPCR arrays