Table 2.

Correlation of the expression of the 35 signature genes with progression-free survival using univariate Cox model

Gene	Contained pathway	Coefficient (β)	HR	p
ABL1	Cell cycle	-0.1215	0.886	0.650
	ErbB pathway
CCNA1	Cell cycle	-0.0899	0.914	0.520
CCND1	Cell cycle	0.0746	1.077	0.620
CCNE1	Cell cycle	-0.4975	0.608	0.032
CDC6	Cell cycle	0.2324	1.262	0.410
CDK2	Cell cycle	-0.5268	0.591	0.150
CDKN1C	Cell cycle	-0.0285	0.972	0.900
CDKN2A	Cell cycle	0.1415	1.152	0.170
	p53 pathway
DKK1	WNT pathway	0.1759	1.192	0.040
FZD3	WNT pathway	0.2434	1.276	0.230
FZD7	WNT pathway	0.4934	1.638	0.022
GADD45G	MAPK pathway	0.2850	1.330	0.200
GHR	JAK-STAT pathway	-0.2292	0.795	0.180
GSTT1	Glutathione metabolism	0.0485	1.050	0.590
HSPA1B	JAK-STAT pathway	-0.1244	0.883	0.340
ID4	TGF- β pathway	-0.1680	0.845	0.350
IGFBP3	p53 pathway	0.1103	1.117	0.340
INHBB	TGF- β pathway	-0.1187	0.888	0.390
IRS2	Insulin signaling	-0.0665	0.936	0.790
LIFR	ErbB pathway	-0.1009	0.904	0.670
PDGFRA	MAPK pathway	0.0262	1.027	0.760
PIK3CA	Phosphatidylinositol signaling	0.1479	1.159	0.420
PLA2G5	Phosphatidylinositol signaling	-0.0176	0.983	0.900
POLE3	Nucleotide excision repair	0.0615	1.063	0.840
PPARGC1A	MAPK pathway	0.4121	1.510	0.045
PRKAR2B	Insulin signaling	0.0641	1.066	0.660
PYGB	Insulin signaling	-0.4071	0.666	0.160
SFRP1	WNT pathway	-0.1216	0.886	0.270
SFRP4	WNT pathway	0.1461	1.157	0.270
SH2B2	Insulin signaling	-0.0199	0.980	0.950
STAG3L4	JAK-STAT pathway	-0.0001	1.000	1.000
STMN1	MAPK pathway	0.0837	1.087	0.750
THBS2	Focal adhesion	-0.1319	0.876	0.330
THBS3	Focal adhesion	-0.3916	0.767	0.160
VEGFA	VEGFA signaling	-0.0268	0.974	0.810