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. 2018 Mar 13;114(5):1009–1017. doi: 10.1016/j.bpj.2018.01.020

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© 2018 Biophysical Society.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Comparison of evolutionary effects on protein dynamics. (A) The change in atom fluctuation (dFLUX) due to gene duplication in serine proteases (compares trypsin PDB: 2ptn to pancreatic elastase PDB: 3est) is shown. (B) Shown are the p-values of the KS tests, with blue indicating significant change. (C) Shown is the R graphical output revealing the average FLUX (top), dFLUX (middle), and KS statistics (bottom) as a function of amino acid position. (D)–(F) show the same results for destabilization of a B-RAF kinase by two cancer mutations (yellow).