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. 2018 Feb 22;20(3):295–303. doi: 10.1016/j.neo.2018.01.005

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© 2018 The Authors. Published by Elsevier Inc. on behalf of Neoplasia Press, Inc.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Dynamic regulation of CD44 and CD24 methylation statuses during apoptosis reversal.

(A and B) Relative expressions (A) and methylation statuses by methylation-specific PCR (B) of CD44 and CD24 in reversed versus solvent control cells. (C and D) Relative expressions (C) and methylation statuses (D) of CD44 and CD24 in CSCs and NCSCs sorted from NSRs. (B and D) MCtrl and UCtrl: methylated and unmethylated bisulfite-converted control human DNA; CD44 M and CD44 U: CD44 methylated- and unmethylated-specific primers; CD24 M and CD24 U: CD24 methylated- and unmethylated-specific primers. (E) FACS analyses of the expressions of CD44 and CD24 in NSR, ANSR (5-Aza-pre-treated NSR) and SNSR (SAM-pre-treated NSR). (F-H) Effects of 5-Aza or SAM pre-treatment on the percentage of CD44⁺/CD24^- cells (F), CD44⁺ cells (G) and CD24⁺ cells (H) in NSR. For A, C, F, G and H, Data represent mean±SEM (n = 3). *P < .05; **P < .01; ***P < .001.