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Electrospun templates with 0–5 mg/mL Cl-Am were implanted subcutaneously on the dorsa of rats. (A) One template was implanted randomly per subcutaneous pocket. In addition, to determine if the drug-eluting materials had systemic effects due to diffusion or convection, (B) SD templates with 0 mg/mL Cl-Am were implanted between SD templates with 5 mg/mL Cl-Am and (C) SD templates with 0 mg/mL Cl-Am were implanted alone.
