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. 2018 Mar 28;9:289. doi: 10.3389/fphar.2018.00289

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Copyright © 2018 Fetz, Neeli, Buddington, Read, Smeltzer, Radic and Bowlin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PDO electrospins at low and high concentrations with Cl-Am. Representative SEMs of (A) SD and (B) LD templates with 0–5 mg/mL Cl-Am (scale bars = 20 μm). For all drug concentrations, all SD and all LD templates have statistically equivalent (C) fiber and (D) pore diameters; however, at each drug concentration, SD templates have significantly smaller (C) fiber and (D) pore diameters than the large diameter templates. ^*Significant difference (p < 0.05). (mean ± std. dev., n > 250 for fiber diameter analysis and n = 60 for pore diameter analysis).