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. 2018 Mar 28;9:289. doi: 10.3389/fphar.2018.00289

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Copyright © 2018 Fetz, Neeli, Buddington, Read, Smeltzer, Radic and Bowlin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SD and LD templates elute Cl-Am over 5 days. From 0 min to 6 h, the (A) SD templates eluted significantly more drug than the (B) LD templates. This trend was observed from 6 h to 5 days for the (C) SD and (D) LD templates. ^*Significant difference between 2.5 mg/mL Cl-Am and 5 mg/mL Cl-Am from 0 mg/mL Cl-Am templates (p < 0.05). ^**Significant difference between 5 mg/mL Cl-Am from 0 mg/mL Cl-Am templates (p < 0.05). ⁺Significant difference between SD and LD templates with 5 mg/mL Cl-Am (p < 0.05). ⁺⁺Significant difference between SD and LD templates with 2.5 mg/mL and 5 mg/mL Cl-Am (p < 0.05). ⁺⁺⁺Significant difference between all SD and LD templates (p < 0.05) (mean ± std. dev., n = 6).