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. 2018 Mar 20;2018:1052413. doi: 10.1155/2018/1052413

Figure 3.

Figure 3

Interaction of two signaling pathways, NRF2 and NFKB1, in human umbilical vascular endothelial cells (HUVEC) exposed to (a) GC-rich and (b) oxidized cfDNA fragments. The expression levels were determined every 5 minutes after adding the corresponding fragments (model GC-rich fragments, model oxidized fragments) using real-time PCR. For each gene, the expression level was calculated relating to the internal standard gene ТВР, with a spread in values at every point not exceeding 5%. ∗Significant difference (p < 0.05) between the relative values of NRF2 and NFKB1.