Table 4.

Median (IQR) VAS scores for spontaneous pain, pain after defecation, and after rectal examination at each time point and results of the mixed-effects linear (MLM) models.

Variable	All patients	Mesoglycan group	Control group	p-value
Spontaneous pain—T1	3 (2–5)	3 (2–4)	4 (3–5)
(i) T2 (ii) T3 (iii) T4	3 (2–4) 2 (0–3) 0 (0–1)	3 (1–4) 1 (0–3) 0 (0–1)	3 (2–4) 2 (2–3) 0 (0–1)
Arm (mesoglycan versus control)				0.122
Pain after defecation—T2	6 (5–7)	6 (4–7)	6 (5–8)
(i) T3 (ii) T4	4 (3–5) 1 (0–2)	3 (2–5) 1 (0–2)	4 (3–5) 2 (1–3)
Arm (mesoglycan versus control)				0.138
Pain after rectal examination—T2	6 (4–8)	5 (3–7)	6 (5–8)
(i) T3 (ii) T4	4 (3–5) 1 (0–2)	4 (2–5) 1 (0–2)	5 (3–6) 2 (0–3)
Arm (mesoglycan versus control)				0.033