Table 5.

Binding energy required for the interaction process.

	Coumarin	Eugenol	TCA
RANKL	−750.88 kJ/mol	−768.91 kJ/mol	−834.33 kJ/mol
RANK–RANKL complex	−850.05 kJ/mol	−773.87 kJ/mol	−746.86 kJ/mol
OPG	−721.53 kJ/mol	−696.04 kJ/mol	−653.57 kJ/mol
RANKL–OPG complex	−649.09 kJ/mol	−687.59 kJ/mol	−642.78 kJ/mol