Table 9.
Summary of the data from the recent studies on the use of Allograft Prosthesis Composite for the management of massive skeletal defects in distal femur.
| Authors | Diagnosis | No of patients | Mean age (years) | Average Follow up | Clinical outcome | Radiological Outcome | Complications | Result | Survival |
|---|---|---|---|---|---|---|---|---|---|
| Moon et al.107 | Tumors | 12 | 19 | 89 m | MSTS score available for 6 patients; | – | 8 patients had complications non-union, fracture, infection and stem perforation | 3 non- union and 2 failures revised | – |
| Average = 90% | |||||||||
| Mo S et al.108 | Tumors | 12 | 29.5 | 45.7 m | MSTS in 9 patients with preserved limb = 27 | – | 1 fracture | 1 died | |
| 1 infection | 4 revisions | ||||||||
| 1 instability | |||||||||
| 1 local recurrence | |||||||||
| Saidi K et al.109 | Fractures | 7 APC | 79 | KSS = 74.1 | – | 1 infection | 3 revisions | ||
| 9 RSA | 1 dislocation | ||||||||
| 7 DFR | 1 non-union | ||||||||
| Ye ZM et al.110 | Tumors | 12 PF | – | 64 m | EFS = 23.4 | No loosening | No dislocation | 3 died | – |
| 10 DF | |||||||||
| 3 PT | |||||||||
| Farfalli et al.111 | Tumors | (Group 1) 50 APC (28 DF, 22 PT) with non-constrained prosthesi |
35 in both | Group 1–69 m | MSTS = 25 in Group 1 | – | Group 1: | Group 1: | Group 1: 69% at 5 years and 62% at 10 years |
| Group 2–75 m | MSTS = 25.3 in Group 2 | 8 infection | 2 died, | ||||||
| (Group 2) 36 APC (17 DF, 19 PT) with constrained prosthesis |
3 fracture | 16 APC removed | Group 2: 80 % at 5 years and 53 % at 10 years | ||||||
| 2 instability | |||||||||
| 1 loosening | Group 2: | ||||||||
| 1 local recurrence | 5 died, | ||||||||
| 1 non-union | 9 APC removed | ||||||||
| Group 2: | |||||||||
| 3 infection | |||||||||
| 3 fracture | |||||||||
| 3 loosening | |||||||||
| Wilkins RM et al .112 | Revision of distal femoral replacement in tumors | 4 | 17 | 59 m | MSTS = 62% | – | No fracture | No revision | |
| No loosening | |||||||||
| No infection |
Abbreviations: m = months, y = years, APC = Allograft Prosthesis Composite, DF = Distal Femur, PT = Proximal Tibia, RSA = revision systems, DFR = Distal Femur Endoprostheis, KSS = Knee Society Score, MSTS = Musculoskeletal Tumor Society Score.