. Author manuscript; available in PMC: 2018 Aug 1.

Published in final edited form as: Twin Res Hum Genet. 2018 Feb;21(1):12–23. doi: 10.1017/thg.2017.72

Table 4.

NVS Environmental Risk Factors, Personality Constructs, Alcohol and Substance Use, Phenotypes, Units of Analysis, and Measures


		Units of Analysis

Constructs	Phenotypes	Participant-Report	Paradigm	Physiological
Risk/Protective Factors	Peer victimization	Multidimensional Peer Victimization Scale^1,2 Index of Peer Relations^1,2 Experiences with close relationships-revised^1,2
	Parent Psychopathology	CIDI-SF¹
	Life events/trauma	Stress and Adversity Inventory ^1,2
	Parenting	Parental Bonding Instrument ¹

Alcohol Use	Severity of Alcohol Use	Alcohol Use Disorder Identification Test ^1,2
Alcohol Use	Expectations of Alcohol Use	Drinking Expectancy Profile ^1,2

Smoking	Severity of Nicotine Use	Fagerstrom Test of Nicotine Dependence ^1,2

Temperament/Personality^*	Neuroticism, extraversion	Eysenck Personality Questionnaire Short Form ^1,2
	Anxiety sensitivity	Anxiety Sensitivity Index ^1,2	CO₂ challenge ^1,2	HRV, SC, RR, TV, HR ^1,2
	Behavioral inhibition/activation	Behavioral Inhibition System/Behavioral Activation System Scales ^1,2
	Unemotionality	Inventory of Callous-Unemotional Traits ^1,2

Not formally included in RDoC matrix

Note. Superscript of 1 = included in wave 1; superscript of 2 = included in wave 2. HRV = heart rate variability; SC = skin conductance; RR = respiration rate; TV = tidal respiratory volume; CIDI-SF= Composite International Diagnostic Interview-Short Form