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. 2018 Feb 4;11(2):300–306. doi: 10.1016/j.tranon.2018.01.003

Figure 1.

Figure 1

CDC7 expression was highly enriched in GBM cells

(A) Genome-wide transcriptome microarray analysis from Mao’s dataset shows that CDC7 is one of the most up-regulated kinase encoding genes in GBM samples compared to normal tissue. (B) Analysis of Mao’s dataset indicated that CDC7 was highly expressed in both mesenchymal and proneural subtypes of GBM compared with normal astrocytes. (C-D) Analysis of TCGA database indicated that CDC7 was highly expressed in all the 4 subgroups of GBM (classical, mesenchymal, neural and proneural) compared with non-tumor tissue. (E) qRT-PCR analysis showed BUB1B mRNA expression was elevated in 6 GBM cell lines (SHG44, T98G, U87, U373, U251 and U138) compared with normal astrocytes (NHA). (F) Western blotting analysis indicated that CDC7 protein expression was enriched in GBM tissue compared with normal brain from the paired patient samples. β-actin served as a control.