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. 2018 Feb 4;11(2):300–306. doi: 10.1016/j.tranon.2018.01.003

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

The CDC7 inhibitor reduced tumorigenicity and radio resistance of GBM. (A) Chemical structure of CDC7 inhibitor PHA-767491. (B) Flow cytometry analysis for apoptosis with Annexin V antibody and Propidium Iodide using U87 cells treated with PHA-767491 or DMSO. (C) Western blotting analysis of U87 cells t treated with PHA-767491 or DMSO. β-actin served as a control. (D) In vitro cell growth assay showed that PHA-767491 decreased cell proliferation of U87 when combined with radiation (P < .05, with t tests). E. Kaplan-Meier analysis was performed for the comparison of survival in U87 implanted mice treat with or without PHA-767491 (P = .0007, with log-rank test).