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. 2018 Mar 20;2018:8470642. doi: 10.1155/2018/8470642

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Copyright © 2018 Bernardo Dias Pereira et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Algorithm for genetic testing in patients with pediatric PHEO, according to clinical presentation, tumor immunohistochemistry, and biochemical profiles. −ve: negative; +ve: positive; ¹⁸F-FDOPA: ¹⁸F-fluorodihydroxyphenylalanine; PHEO: pheochromocytoma; PGL: paraganglioma; A: adrenaline; D: dopamine; NA: noradrenaline; FH: fumarate hydratase gene; HIF2A: hypoxia-inducible factor 2 alpha gene; MAX: Myc-associated protein X gene; NF1: neurofibromatosis type 1 gene; PHD1: prolyl hydroxylase domain protein 1 gene; RET: rearranged during transfection gene; SDHA: succinate dehydrogenase subunit A gene; SDHA: succinate dehydrogenase subunit A protein; SDHB: succinate dehydrogenase subunit B gene; SDHB: succinate dehydrogenase subunit B protein; SDHC: succinate dehydrogenase subunit C gene; SDHD: succinate dehydrogenase subunit D gene; VHL: von Hippel-Lindau gene. ^∗Consider SDHC mutations (PGL; PHEO reported only in patients > 18 years).