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. Author manuscript; available in PMC: 2019 Mar 22.
Published in final edited form as: Cell. 2018 Mar 22;173(1):74–89.e20. doi: 10.1016/j.cell.2018.02.008

Figure 3. SIRT1 is required for angiogenesis in vitro.

Figure 3

(A) Number of migrated MLECs (n = 12).

(B) Images, number of branch points and length of tube networks formed by MLECs (n = 5).

(C) Images and sprout length of MLEC spheroids (n = 8).

(D) Images, number and total area of microvessel sprouts in aortic rings (n = 8).

(E) Images, number of branch points and length of tube networks formed by HAECs infected with lentivirus expressing scrambled (Scr) or SIRT1 (T1) shRNA (n = 8).

(F) Number of migrated HAECs (n = 8).

Data are expressed as mean ± SEM. *p < 0.05, **p < 0.005, ***p < 0.0005, δp < 0.00005 by Student’s t test (C), one-way (D–F) or two-way (A–B) ANOVA with Bonferroni’s corrections. See also Figure S3