Table 2.

Tumor and Proliferation Markers in High-Grade Serous Carcinoma (HGSC) vs. Other Epithelial Ovarian Tumors^a

	HGSC		Other Tumorsa		P
	(n = 26)		(n = 43)
	n	%	n	%
Tumor marker
p53b	24	92.3	10c	23.8	<.001
p16d	26	100	26	60.5	<.001
Proliferation marker
Ki67e	19	73.1	16	37.2	<.005

^aOther tumors = endometrioid carcinoma, clear cell carcinoma, mucinous carcinoma, low-grade serous carcinoma, carcinosarcoma, mixed tumor, non-differentiated carcinoma, mucinous cystadenoma and borderline ovarian tumor.

^bTumors were scored with respect to distribution (0-4) and intensity (1-3) of immunoreactivity. An immunohistochemical composite score was calculated by multiplying the distribution and intensity scores (0-12). Score 0 and 12 were considered as p53 mutation.

^cOne case was not evaluated due to technical problems with immunohistochemical staining.

^d>25% Moderat/intense diffuse nuclear staining was considered as p16 mutation.

^eHigh Ki67 proliferation (> 25% stained cells).