Table 4.

Chlamydial Plasma Antibodies in Relation to Tumor Characteristics, Chlamydia trachomatis and Chlamydial Heat Shock Protein 60 in Ovarian Tissue

	C. trachomtis IgG		P	cHSP60 IgG		P
	(n = 69)			(n = 33)a
	n / N	%		n / N	%
Tumor characteristics
HGSC	4 / 26	15.4	0.46	7 / 11	63.6	0.33
Other tumorsb	4 / 43	9.3		10 / 22	45.5
Invasive	6 / 48	12.5	1.00	12 / 20	60.0	0.23
Non-invasivec	2 / 21	9.5		5 / 13	38.5
C. trachomatisd
Positive	2 / 8	25.0	0.23	2 / 3	66.7	1.00
Negative	6 / 61	9.8		15 / 30	50.0
chsp60e
Positive	3 / 30f	10.0	1.00	7 / 17	41.2	0.22
Negative	4 / 38f	10.5		10 / 16	62.2

Abbreviations: cHSP60 IgG = chlamydial heat shock protein 60 IgG; HGSC = high-grade serous carcinoma.

^acHSP60 IgG optical density values using ELISA were categorized in quartiles. Highest and lowest quartiles were compared.

^bOther tumors = endometrioid carcinoma, clear cell carcinoma, mucinous carcinoma, low-grade serous carcinoma, carcinosarcoma, mixed tumor, non-differentiated carcinoma, mucinous cystadenoma and borderline ovarian tumor.

^cBorderline ovarian tumor, n = 20; Mucinous cystadenoma, n = 1.

^dC. trachomatis DNA analyzed with PCR.

^eIntense staining of nucleus was considered chsp60 positive.

^fOne case was not evaluated due to technical problems with immunohistochemical staining.