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. 2018 Feb 20;11(2):426–435. doi: 10.1016/j.tranon.2018.01.022

Figure 3.

Figure 3

Higher antitumor effect of nab-paclitaxel (NPT) on esophageal adenocarcinoma tumor xenografts inhibiting growth of established local tumor without significant change in mice body weight. OE19 cells were subcutaneously injected in athymic nude mice and treated with carboplatin (CP), paclitaxel (PT), nab-paclitaxel (NPT) as a monotherapy and in combinations. (A and B) Relative tumor volume (RTV) changes after treatments were compared. Relative tumor volume is calculated by dividing the tumor volume at any time by the tumor volume at the start of treatment. (A) RTV changes over a period of 2 weeks treatments of indicated drugs. (B) RTV changes after indicated treatments were compared at day 14. (C) Mouse body weight was measured twice a week and presented as bar chart for the 2-week therapy period. (D) Mean tumor weight was calculated from final day tumor weights in each group. Data are representative of mean values ± standard deviation. * indicates p < 0.05 in PT versus NPT, ** indicates p < 0.05 in PT+CP versus NPT+CP. All N=5 mice/group.