Table 1.

Non-metal and metalloid metabolic products - Select organic compounds with rare element incorporations (including halogens, non-metals, and metalloids) generated in vivo, both natural and engineered, are provided in order of their appearance. (*) Denotes completely unnatural products.

Element	Highlighted Compounds	Organism(s)	Engineered vs. Natural	Titer	References
Fluorine	Fluorosalinosporamide*	Salinispora tropica	Engineered	1.5 mg/L	Eustaquio and Moore [167]
	Nucleocidin	Streptomyces calvus	Natural	N/A	Zhu et al. [42]
	Fluorinated rapamycin analogues*	Streptomyces hygroscopicus	Engineered, precursor directed	5-28 mg/L	Goss et al. [44]
	Fluorinated tetraketide lactones*	E. coli	Engineered, precursor directed	N/A	Walker et al. [45]
Chlorine	2-chloro-resveratrol*	E. coli	Engineered	7.0 mg/L	Wang et al. [61]
	5-chloro daurichromenicacid*	Aspergillus oryzae	Engineered	2.06 mg/L	Okada et al. [55]
	8-chloro-7-hydroxycoumarin*	E. coli	Engineered	1.1 mg/L	Menon et al. [64]
	Chloramphenicol	Streptomyces avermitilis	Engineered	250 mg/L	Komatsu et al. [70]
Bromine	Bromoalterochromide A	E. coli	Engineered	N/A	Ross et al. [72]
	Bromophenols, bromocatechols, and related molecules	E. coli	Engineered	N/A	Agarwal et al. [73]
	7-bromo-tryptophan and bromo-pacidamycin D*	E. coli	Engineered	N/A	Sharma et al. [74]
Iodine	Methyl iodide	E. coli, S. cerevisiae	Engineered		Bayer et al. [80]
	Iodocionin	Ciona edwardsii	Natural	N/A	Aiello et al. [78]
Selenium	Dimethyldiselenide	E. coli	Engineered	N/A	Swearingen et al. [168]
	2-selenouridine	E. coli, Methanococcus vannielii, Clostridium sticklandii, etc.	Natural	N/A	Sun et al. [101]
	Selenobiotin	Phycomyces blakesleeanus	Natural	N/A	Sum bui et al. [169]
Boron	Borophycin and structurally related compounds	Nostoc spongiaeforme, Teredinibacter turnerae, etc.	Natural	N/A	Dembitsky et al. [170] Elshahawi et al. [171]
	Borolithochromes	Solenopora jurassica	Natural	N/A	Wolkenstein et al. [109]
Silicon	Acetyldimethylphenylsilane*	Kloeckera cortices	Natural, precursor directed	N/A	Frampton and Zelisko [113]
	Dimethylphenylsilane diol products*	E. coli	Engineered, precursor directed	>10g scale	Smith et al. [118]
	α-hydroxy silanes*	S. cerevisiae	Natural, precursor directed	N/A	Zani [117]
	Ethyl 2-((4-aminophenyl)dimethylsilyl)propanoate*	E. coli	Engineered, precursor directed	N/A	Kan et al. [119]
Tellurium	Methanetellurol	E. coli	Engineered	N/A	Swearingen et al. [121]
	Dimethyl tellurenyl sulfide	E. coli	Engineered	N/A	Swearingen et al. [121]