Fluorine |
Fluorosalinosporamide* |
Salinispora tropica |
Engineered |
1.5 mg/L |
Eustaquio and Moore [167]
|
Nucleocidin |
Streptomyces calvus |
Natural |
N/A |
Zhu et al. [42]
|
Fluorinated rapamycin analogues* |
Streptomyces hygroscopicus |
Engineered, precursor directed |
5-28 mg/L |
Goss et al. [44]
|
Fluorinated tetraketide lactones* |
E. coli |
Engineered, precursor directed |
N/A |
Walker et al. [45]
|
Chlorine |
2-chloro-resveratrol* |
E. coli |
Engineered |
7.0 mg/L |
Wang et al. [61]
|
5-chloro daurichromenicacid* |
Aspergillus oryzae |
Engineered |
2.06 mg/L |
Okada et al. [55]
|
8-chloro-7-hydroxycoumarin* |
E. coli |
Engineered |
1.1 mg/L |
Menon et al. [64]
|
Chloramphenicol |
Streptomyces avermitilis |
Engineered |
250 mg/L |
Komatsu et al. [70]
|
Bromine |
Bromoalterochromide A |
E. coli |
Engineered |
N/A |
Ross et al. [72]
|
Bromophenols, bromocatechols, and related molecules |
E. coli |
Engineered |
N/A |
Agarwal et al. [73]
|
7-bromo-tryptophan and bromo-pacidamycin D* |
E. coli |
Engineered |
N/A |
Sharma et al. [74]
|
Iodine |
Methyl iodide |
E. coli, S. cerevisiae |
Engineered |
|
Bayer et al. [80]
|
Iodocionin |
Ciona edwardsii |
Natural |
N/A |
Aiello et al. [78]
|
Selenium |
Dimethyldiselenide |
E. coli |
Engineered |
N/A |
Swearingen et al. [168]
|
2-selenouridine |
E. coli, Methanococcus vannielii, Clostridium sticklandii, etc. |
Natural |
N/A |
Sun et al. [101]
|
Selenobiotin |
Phycomyces blakesleeanus |
Natural |
N/A |
Sum bui et al. [169]
|
Boron |
Borophycin and structurally related compounds |
Nostoc spongiaeforme, Teredinibacter turnerae, etc. |
Natural |
N/A |
Dembitsky et al. [170] Elshahawi et al. [171]
|
Borolithochromes |
Solenopora jurassica |
Natural |
N/A |
Wolkenstein et al. [109]
|
Silicon |
Acetyldimethylphenylsilane* |
Kloeckera cortices |
Natural, precursor directed |
N/A |
Frampton and Zelisko [113]
|
Dimethylphenylsilane diol products* |
E. coli |
Engineered, precursor directed |
>10g scale |
Smith et al. [118]
|
α-hydroxy silanes* |
S. cerevisiae |
Natural, precursor directed |
N/A |
Zani [117]
|
Ethyl 2-((4-aminophenyl)dimethylsilyl)propanoate* |
E. coli |
Engineered, precursor directed |
N/A |
Kan et al. [119]
|
Tellurium |
Methanetellurol |
E. coli |
Engineered |
N/A |
Swearingen et al. [121]
|
Dimethyl tellurenyl sulfide |
E. coli |
Engineered |
N/A |
Swearingen et al. [121]
|