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Impairment of ADCC against primary CLL cells by kinase inhibitors. The antibody-dependent increase in the percentages of minimal calcein retention was determined in six or seven independent experiments with 3-fold excess of recombinant 26.5 (a) or 1708-LC3E11 (b) effector cells over CLL target cells. Cytotoxicity was compared to controls without antibodies by paired two-tailed t-test. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001.
