Table 1.

Study objectives and outcome measures.

Study objective	Outcome measures
Primary
To determine whether perfusion-based, ce-MRI can differentiate pleural malignancy from benign pleural disease with comparable or superior sensitivity and specificity to subjective CT or MRI morphology assessment	Diagnostic classification based on •MRI contrast enhancement pattern •CT morphology assessment •MRI morphology assessment
	Diagnostic assessment including pleural biopsy results
Secondary
To determine whether there is a correlation between contrast enhancement pattern at MRI and tumour vascularity	•Mean Signal Intensity Gradient at ce-MRI •Tumour MVD based on Factor VIII immunostaining in FFPE pleural biopsies •Inter-observer agreement (Cohen’s Kappa) •Intra-observer agreement for ECE only (Cohen’s Kappa)
To determine the reproducibility of ECE, CT and MRI morphology
Exploratory
To determine whether there is an association between: 1.ce-MRI parameters and Survival 2.Tumour vascularity and Survival	•MSIG at ce-MRI •Overall Survival (months) •Tumour MVD (Factor VIII immunostaining in FFPE pleural biopsies) •Overall Survival (months)

ce-MRI; Contrast-enhanced Magnetic Resonance Imaging, CT; Computed Tomography, ECE; Early Contrast Enhancement, FFPE; Formalin-Fixed Paraffin-Embedded; MVD; Micro-vessel Density.