Table 2.
The diagnostic performance and reproducibility of CT morphology, MRI morphology and MRI-Early Contrast Enhancement (ECE) assessed in 58 patients with suspected Pleural Malignancy. Agreement was assessed using Cohen’s Kappa statistic. Diagnostic performance between groups is compared by McNemar’s test, adjusted for multiple comparisons. Statistically significant differences before and after adjustment are highlighted below.
| CT Morphology | MRI Morphology | MRI-ECE | Combined MRI Morphology-ECE | |
|---|---|---|---|---|
| Sensitivity (95% CI) | 56% (37–72%) | 68% (48–83%) | 83%* (61–94%) | 92%** (67–100%) |
| Specificity (95% CI) | 77% (60–89%) | 85% (69–93%) | 83% (68–91%) | 78% (64–87%) |
| PPV (95% CI) | 68% (47–84%) | 77% (57–90%) | 68% (47–84%) | 55% (35–73%) |
| NPV (95% CI) | 67% (50–80%) | 78% (62–88%) | 92% (78–97%) | 97% (86–100%) |
| Inter-observer Agreement | 0.65 | 0.593 | 0.784 | N/R |
| Intra-observer Agreement | N/R | N/R | 0.864 | N/R |
CT; Computed Tomography, MRI; Magnetic Resonance Imaging, CI; Confidence Interval, PPV; Positive Predictive Value, NPV; Negative Predictive Value, N/R; Not Recorded.
Unadjusted p value .022 but adjusted p value .066 (MRI-ECE vs. CT morphology).
Unadjusted p value .016 but adjusted p value .66 (Combined MRI morphology and ECE assessment vs. MRI morphology). For all other comparisons p > .05.