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. 2018 Jan 15;17(2):250–262. doi: 10.1080/15384101.2017.1417708

Figure 8.

Figure 8.

The major pro-apoptosis mechanism contributed by miR-200a in ALD. Ethanol treatment elevate the level of miR-200a expression, which could directly binding to ZEB2 and subsequently suppress ZEB2 expression. ZEB2 depletion resulted in the inhibition of Bcl-2 and facilitation of Bax, which are landmark protein of apoptosis.