TABLE 2.
Protein binding data for experiments 1 and 2
Drug concentration in plasma (total opioid; heroin + 6-AM + morphine) 4 minutes after intravenous administration of a low or high opioid dose. *P < 0.05 for the difference between vaccine and control groups given the same dose. Unpaired t tests were used to compare groups. Mean ± S.D., n = 6–8/group.
| Heroin Dose |
Drug Concentration in Plasma |
||
|---|---|---|---|
| Total |
Unbound |
Bound |
|
| μmol/kg (mg/kg) | μM | μM | % |
| KLH | |||
| 0.7 (0.26) | 0.26 ± 0.09 | 0.12 ± 0.06 | 52.9 ± 11.7 |
| 7.0 (2.6) | 2.75 ± 0.33 | 0.82 ± 0.17 | 70.0 ± 6.7 |
| M-KLH | |||
| 0.7 (0.26) | 4.03 ± 1.20* | 0.08 ± 0.13 | 97.0 ± 5.8* |
| 7.0 (2.6) | 8.17 ± 1.94* | 0.87 ± 0.23 | 88.5 ± 5.1* |