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. 2018 Jan 19;17(2):162–173. doi: 10.1080/15384101.2017.1361066

Figure 1.

Figure 1.

Testicular phenotypes of WT, RNF8−/− and RAD6B−/− mice. (A) Three-month-old (3 m) and 6-month-old (6 m) WT, RNF8−/− and RAD6B−/− males were mated with WT females of the same age. The numbers of pups are shown. All values are presented as the mean ± SEM (WT n = 6; RNF8−/− n = 6; RAD6B−/− n = 6). Student's t-test; ***P < 0.001, ****P < 0.0001. (B) Pictures of normal testes from 6-month-old wild-type (WT) male mice and of testes from 6-month-old RNF8 knockout (KO) male mice and 6-month-old RAD6B knockout male mice are shown. (C) Images of H&E-stained sections of seminiferous tubules from 6-month-old WT, RNF8−/− and RAD6B−/− mice. H&E staining of testis sections from RAD6B−/− males showed a dramatic reduction in germ cells compared with RNF8−/− males. Bar, 20 μm.