Skip to main content
. Author manuscript; available in PMC: 2018 Apr 4.
Published in final edited form as: Sci Transl Med. 2017 May 3;9(388):eaah6122. doi: 10.1126/scitranslmed.aah6122

Fig 2. Template validation.

Fig 2

(A) Average background EEG activity and the average evoked activity following visual, tactile, auditory and experimental noxious stimulation at the Cz electrode in 14 term infants. (B) Magnitude of the nociceptive brain activity characterized by the template during the background activity and in response to each experimental stimulus modality (visual, tactile, auditory and experimental noxious stimulation). (C) Average background EEG activity and the average evoked activity following experimental noxious and non-noxious stimulation for all stimuli that evoked a change in heart rate that was greater than the average change in heart rate evoked by the experimental noxious stimulation. (D) Magnitude of the nociceptive brain activity during background activity and following the experimental noxious and non-noxious stimulation that evoked larger than average changes in heart rate. (E) Average background EEG activity at the Cz electrode in 12 preterm infants (from 34 – 36 weeks’ gestation) and the average evoked activity following control heel lance stimulation and a medically required heel lance. (F) Magnitude of the nociceptive brain activity during the background activity and in response to control heel lance stimulation and a medically required heel lance. In panels (A,C,E) average EEG activity is overlaid with the template (in red). (B,D,F) The magnitude of the projected template is shown for each condition with mean ± standard error of the mean (**: p < 0.01).