Table 1.
Expression of actin-binding proteins cofilin and N-WASP in human laryngeal cancer in relation to clinical and pathological parameters.
| Cofilin cytoplasmic expression | p value | Cofilin nuclear expression | p value | N-WASP expression | p value | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Low (n, %) |
High (n, %) |
Low (n, %) |
High (n, %) |
Low (n, %) |
High (n, %) |
|||||||||||
| Age | ≤60 | 18 | 51.4% | 17 | 48.6% | 0.825 | 28 | 80.0% | 7 | 20.0% | 0.155 | 14 | 40.0% | 21 | 60.0% | 0.782 |
| >60 | 20 | 54.1% | 17 | 45.9% | 24 | 64.9% | 13 | 35.1% | 16 | 43.2% | 21 | 56.8% | ||||
|
| ||||||||||||||||
| Location | Glottis | 21 | 48.8% | 22 | 51.2% | 0.698 | 32 | 74.4% | 11 | 25.6% | 0.729 | 15 | 34.9% | 28 | 65.1% | 0.115 |
| Supraglottis | 16 | 59.3% | 11 | 40.7% | 19 | 70.4% | 8 | 29.6% | 15 | 55.6% | 12 | 44.4% | ||||
| Subglottis | 1 | 50.0% | 1 | 50.0% | 1 | 50.0% | 1 | 50.0% | 0 | 0.0% | 2 | 100.0% | ||||
|
| ||||||||||||||||
| Grade | Grade I | 7 | 53.8% | 6 | 46.2% | 0.981 | 10 | 76.9% | 3 | 23.1% | 0.634 | 2 | 15.4% | 11 | 84.6% | 0.031 |
| Grade II | 26 | 53.1% | 23 | 46.9% | 36 | 73.5% | 13 | 26.5% | 21 | 42.9% | 28 | 57.1% | ||||
| Grade III | 5 | 50.0% | 5 | 50.0% | 6 | 60.0% | 4 | 40.0% | 7 | 70.0% | 3 | 30.0% | ||||
|
| ||||||||||||||||
| N | No | 28 | 52.8% | 25 | 47.2% | 0.988 | 36 | 67.9% | 17 | 32.1% | 0.177 | 21 | 39.6% | 32 | 60.4% | 0.560 |
| N1–3 | 10 | 52.6% | 9 | 47.4% | 16 | 84.2% | 3 | 15.8% | 9 | 47.4% | 10 | 52.6% | ||||
|
| ||||||||||||||||
| Stage | I | 1 | 100.0% | 0 | 0.0% | 1 | 100.0% | 0 | 0.0% | 0 | 0.0% | 1 | 100.0% | |||
| II | 3 | 75.0% | 1 | 25.0% | 3 | 75.0% | 1 | 25.0% | 3 | 75.0% | 1 | 25.0% | ||||
| III | 14 | 56.0% | 11 | 44.0% | 0.510 | 18 | 72.0% | 7 | 28.0% | 0.960 | 13 | 52.0% | 12 | 48.0% | 0.135 | |
| IV | 20 | 47.6% | 22 | 52.4% | 30 | 71.4% | 12 | 28.6% | 14 | 33.3% | 28 | 66.7% | ||||
Statistical analyses were performed by nonparametric tests, and p < 0.05 was considered statistically significant. Lymph node (N) metastasis and stage were determined based on TNM, 7th edition [33].