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. 2018 Mar 28;38(13):3177–3189. doi: 10.1523/JNEUROSCI.3368-17.2018

Figure 1.

Figure 1.

Coabsence of mucolipins 3 and 1 in HCs, but not either alone, causes age-related hearing loss progressing from high to low frequencies. A–H, Hearing thresholds at 27 and 12 kHz determined using ABRs (A, C, E, G) and DPOAEs (B, D, F, H) in adult (∼P60–P120) and juvenile (∼P30) mice. A, B, Adult mice lacking both mucolipins 3 and 1 (DKO), but not either alone (ML1KO or ML3KO), have raised ABR (A) and DPOAE (B) thresholds at 27 kHz compared with WT mice. Juvenile DKO mice (∼P30) exhibit somewhat smaller threshold shifts at 27 kHz for both ABR and DPOAE. C, D, Adult DKO mice have a mild hearing loss at 12 kHz indicated by both ABR (C) and DPOAE (D) threshold shifts. At 12 kHz, juvenile DKO mice have intermediate ABR and DPOAE threshold shifts. E–H, Hearing tests from mice in which mucolipins 3 and 1 are conditionally absent in HCs only (cDKO) indicate that adult cDKO mice (∼P120) have raised hearing thresholds at both 27 (E, F) and 12 (G, H) kHz. Age-matched (P120) data from adult DKO mice from (A–D) were selected and replotted (E–H) to statistically compare the ABR (E, G) and DPOAE (F, H) thresholds between mice lacking mucolipins in all cells versus mice lacking mucolipins in HCs only. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.