Figure 5.

Deletion of PGC-1α in MSNs results in age-related hypoactivity. Ambulatory activity of mice lacking PGC-1α specifically in MSNs was assessed in the open field. A, Mice up to the age of 6 months showed no differences between genotypes in ambulatory distance throughout the test session. B, Mice at 18 months of age exhibited hypoactivity throughout the test session. C, D, There was a lack of genotype-dependent effect on d-amphetamine-induced ambulation at 6 months (C) or 18 months (D) of age. n/genotype are indicated on histograms. *p < 0.05, repeated-measures ANOVA. Data are presented as mean ± SEM.