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. 2018 Mar 28;38(13):3346–3357. doi: 10.1523/JNEUROSCI.3245-17.2018

Figure 3.

Figure 3.

Altered Cox2 and cPLA2 signaling in LGI1−/− (KO) mice. A, Expression of Cox2 in the developing cortex in WT and KO mice. n = 5/group. B, Percentage changes of Cox2 activity in cortex from WT and KO mice. n = 5/group. C, Temporal cortical lysates from WT and KO mice (P7) immunoblotted with antibodies. GAPDH was the internal control. Histogram represents percentage change of pcPLA2 relative to WT. n = 4/group. D, Primary cultured cortical neurons (DIV 14) transfected with myc-tagged myc-LGI1. GAPDH was the internal control. Histogram represents percentage change of pcPLA2 relative to WT. n = 4/group. E, Expression of Cox1, 5-, 12-, 15-lipoxygenase (5-, 12-, 15-Lox), and LGI1 in temporal cortex from WT and KO mice at P7 and P14. GAPDH was the loading control. Histogram represents percentage changes of each protein relative to the corresponding control. n = 6/group. *p < 0.05, **p < 0.01.