Table 2.
Electrophysiological properties of neurons in mice at P14-P17
| Parameter | Temporal lobe |
Prefrontal lobe |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| L5 pyramidal neuron |
L2/3 parvalbumin-positive interneuron |
L2/3 pyramidal neuron + picrotoxin |
L2/3 pyramidal neuron + MEC + atropine |
L2/3 pyramidal neuron |
||||||
| WT | KO | WT | KO | WT | KO | WT | KO | WT | KO | |
| ISI (ms) | 64.1 ± 17.6 | 52.1 ± 11.2** | 26.5 ± 6.1 | 25.4 ± 6.5 | 40.7 ± 6.6 | 33.4 ± 4.1*** | 45.0 ± 21.4 | 36.7 ± 22.2** | 46.7 ± 12.4 | 37.0 ± 7.9** |
| Rheobase (pA) | 138 ± 36 | 114 ± 23.2* | 105 ± 32.5 | 91 ± 25.3 | 122 ± 20.6 | 101 ± 20.6*** | 108 ± 21.8 | 95 ± 17.4** | 133 ± 19.4 | 99 ± 29.9*** |
| RMP (mV) | −63 ± 4 | −64 ± 3.9 | −68 ± 3.6 | −66 ± 3.61 | −62 ± 4.1 | −63 ± 4.11 | −66 ± 8.7 | −64 ± 8.7 | −72 ± 3.9 | −70 ± 3.9 |
| Input resistance (mΩ) | 114 ± 36 | 133 ± 27.1 | 277 ± 61.4 | 267 ± 68.6 | 146 ± 24.7 | 158 ± 20.6 | 151 ± 43.6 | 149 ± 39.2 | 160 ± 46.4 | 164 ± 29.9 |
| No. of cells (mice) | 17 (7) | 16 (7) | 14 (7) | 14 (7) | 18 (5) | 18 (5) | 20 (6) | 20 (6) | 16 (6) | 15 (6) |
*p < 0.05,
**p < 0.01,
***p < 0.001, compared with corresponding WT. KO: Lgi1−/−.